Lung Mechanotransduction, the minuet of Biophysics (Part 1)

Aurio Fajardo-Campoverdi, Yolanda López-Fernández, Paulina Vivanco, Miguel Ibarra-Estrada, Alejandro González-Castro, Alberto Medina, Elena Ortega

Abstract

The dynamic processes associated with lung pathophysiology have always been explored from a traditionalist perspective. This review conceptualizes an amalgam of biological and biophysical concepts that aim to optimize the understanding of the pathophysiology associated with lung injury from a broader, more complex, and at the same time more complete perspective using arguments from the exact sciences. We hypothesize that the Anti-Zener model could be a more accurate potential explanatory model to support mechanotransduction.

In this part we will discuss the concepts of mechantransduction, mechanobiology, stress, strain, strain rate, resilience, alveolar anisotropy, and the role of surfactant.

Keywords:  Mechanotransduction, Young´s modulus, Zener model, Stress, Strain

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