Lung Mechanotransduction, the minuet of Biophysics (Part 2)

Aurio Fajardo-Campoverdi, Yolanda López-Fernández, Paulina Vivanco, Miguel Ibarra-Estrada, Alejandro González-Castro, Alberto Medina, Elena Ortega

Abstract

The dynamic processes associated with lung pathophysiology have always been explored from a traditionalist perspective. This review conceptualizes an amalgam of biological and biophysical concepts that aim to optimize the understanding of the pathophysiology associated with lung injury from a broader, more complex, and at the same time more complete perspective using arguments from the exact sciences. We hypothesize that the Anti-Zener model could be a more accurate potential explanatory model to support mechanotransduction.

The Anti-Zener model represents a more accurate and structured tool to describe the viscoelastic behavior of lung tissue, overcoming the limitations of classical models such as Young’s modules This approach allows a better understanding of pathophysiological processes in the respiratory system, which could optimize treatments for lung diseases such as ARDS and asthma. The integration of exact sciences in the study of lung viscoelasticity opens new possibilities for improving medical care and the design of biomedical materials.

Keywords:  Mechanotransduction, Young´s modulus, Zener model, Stress, Strain

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